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Common Genetic Pathways Implicated RA and SLE Rheumatoid arthritis and lupus are distinct conditions that present in unique ways, but they do share various genetic risk factors. A recent study revealed a new risk locus for both diseases. Previously, the genetic overlap between the two hadn’t been thoroughly examined. But, a study published in the May Annals of Rheumatic Diseasesidentified additional risk loci that are shared between rheumatoid arthritis and